For approaching biomesogen self-organizations in nucleic acid (peptide) assemblies from the perspective of interacting individual macromolecules and their integrating collective mesophase organizations, DNA duplex as well as RNA duplex, triplex, quadruplex and duplex/peptide domains and microdomains have been visualized as graphite surface adlayers by scanning force microscopy. Derived from corresponding mesophase designs, the adlayer imagings of dsDNA, dsRNA and qsRNA reveal aligned supramolecular bundles that follow self-organizational strategies within the adlayer/interface restrictions. For tsRNA and dsRNA/oligo- and polypeptide variations more complex adlayer organizations are observed.